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Basic Copper Sulphate (WSDTY) various anti-inflammatory properties have been demonstrated for glucosamine in the three main tissues involved in OA: cartilage, synovial membrane and subchondral bone. Particularly glucosamine was able to reverse the pro-catabolic and pro-inflammatory effects of IL-1β in articular chondrocytes. IL-1β activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). In human C-20/A4 chondrocytes the NADPH oxidase Nox4 is the main source of ROS production upon IL-1β stimulation. Since heme molecules are essential for the NADPH oxidase maturation and activity, induction of HO-1 expression decreased dramatically Nox4 activity in C-20/A4 and HEK293 Nox4 cell lines. In this context, HO-1 led to a significant decrease of the expression of the MMP1, DNA fragmentation and cell death.

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asked Aug 5, 2019 in Preguntas Comerciales by anonymous

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